![]() As per pathological analyses to date, respiratory organs are identified as the major affected organs in most COVID-19 cases also, various lesions were noted in other organs. Pathological analyses in particular play an important role to demonstrate the causal link between an infectious disease and the pathogen and elucidate the mechanism of pathogenesis. Thus, sufficient understanding of the pathophysiology of COVID-19 is essential to develop effective therapeutics for this disease. The development of treatments for COVID-19 is currently in progress however, their effects remain limited, and the development of more effective therapeutics is desired. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.Since the first case of COVID-19 was reported in Wuhan, China, in December 2019, the SARS-CoV-2 epidemic has spread all over the world and has become a significant public health issue. Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio, 3.4 p < 0.01), male sex (aOR, 3.7 p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8 p = 0.04). Ninety-six (43%) patients had a postoperative change in diagnosis. No difference was observed in HCA-subtype distribution between small and large tumors. Independent risk factors for change in diagnosis were tumor size 50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). ![]() We analyzed indications and outcome of patients operated for HCAs 50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). Data on the indication for surgery are scarce. N2 - Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases. T2 - Indications and pathological discordance T1 - A nationwide assessment of hepatocellular adenoma resection Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.", Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.Ībstract = "Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation.
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